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KMID : 0604520060320030129
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Journal of the Society of Cosmetic Scientists of Korea
2006 Volume.32 No. 3 p.129 ~ p.134
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Effect of Antioxidation and Inhibition of Matrix Metalloproteinase-1 from Ligularia fischeri
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Na Young
Kim Jin-Hwa
Sim Gwan-Sub
Lee Beom-Cheon
Pyo Hyeong-Bae
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Abstract
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In this study, we examined the effects of antioxidant, lipid peroxidation inhibition and suppression of UVA-induced MMP-1 expression in human dermal fibroblasts. Ligularia fischeri extract showed free radical scavenging effect by 82.3% at 5 mg/mL and superoxide radical scavenging effect by 79.3% at 5 mg/mL in the kanthine/xanthine oxidase system, respectively. At the concentration of 500{mu}g/mL, L. fischeri extract showed 97% inhibition on lipid peroxidation of linoleic acid. UVA induced MMP expression in human dermal fibroblasts was reduced 35% by treatment with 100{mu}g/mL of L. fischeri extract. These results suggest that L. fischeri extract can be used for an anti-aging agent by antioxidation, lipid peroxidation inhibition and reducing UVA-induced MMP-1 production.
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KEYWORD
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Ligularia fischeri, antioxidation, MMP-1, human dermal fibroblast, anti-aging
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